Assistant Professor Shinya Miyazaki

Qualifications

PhD（Pharmacy）, Pharmacist

Personal/work Web page addresses

Background

• Apr 2024-Present
  Assistant professor. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki university, Japan
  
• Apr 2020-March-2024
  Assistant professor. Department of Cellular Architecture Studies, Institute of Tropical Medicine (NEKKEN), Nagasaki university, Japan
  
• Apr 2017-March-2020
  Postdoctoral fellow. Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
• Apr 2012-March-2017
  Postdoctoral fellow. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
• Apr 2007-March-2012
  Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.

Research

• Establishment of a platform to assess the cytoadhesion of Plasmodium falciparum-infected erythrocytes to human cells’
• Molecular mechanisms of interactions between Plasmodium falciparum-infected erythrocytes and bone marrow cells’
• Development of Plasmodium falciparum reporter lines for the biology and drug discovery’.
• Analysis of pathogenicity and transmissibility using Plasmodium falciparum field strains’

The country/countries where you work currently

• Japan

Five MOST IMPORTANT/INTERESTING recent publications

1. Miyazaki Y^†, Vos MW, Geurten FJA, Bigeard P, Kroeze K, Yoshioka S, Arisawa M, Inaoka DK, Soulard V, Dechering KJ, Franke-Fayard B, Miyazaki S^†. A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays. Communications Biology. 2023 Jul. doi: 10.1038/s42003-023-05078-5 (^†Corresponding author)
2. Tokumasu F^†, Hayakwa EH, Fukumoto J, Miyazaki S^†. Creative Interior Design by Plasmodium falciparum~ Lipid metabolism and parasite’s secret chamber~Parasitol Int. 2021 Apr 24;83:102369. (^†Corresponding author)
3. Miyazaki S, Chitama BA, Kagaya W, Lucky AB, Zhu X, Yahata K, Morita M, Takashima E, Tsuboi T, Kaneko O. Plasmodium falciparum SURFIN_4.1 forms an intermediate complex with PTEX components and Pf113 during export to the red blood cell. Parasitol Int. 2021 Apr 24;83:102358.
4. Miyazaki S^†, Yang ASP, Geurten FJA, Marin-Mogollon C, Miyazaki Y, Imai T, Kolli SK, Ramesar J, Chevalley-Maurel S, van Gemert GJ, van Waardenburg YM, Franke-Fayard B, Hill AVS, Sauerwein RW, Janse CJ^†, Khan SM. Generation of novel Plasmodium falciparum NF135 and NF54 lines expressing fluorescent reporter proteins under the control of strong and constitutive promoters. Front Cell Infect Microbiol. 2020 Jun 10;10:270. doi: 10.3389/fcimb.2020.00270. (^†corresponding author)
5. Chitama BA*, Miyazaki S*, Zhu X*, Kagaya W, Yahata K, Kaneko O. Multiple charged amino acids of Plasmodium falciparum SURFIN_4.1 N-terminal region are important for efficient export to the red blood cell. Parasitol Int. 2019 Aug;71:186-193. doi:10.1016/j.parint.2019.04.019. Epub 2019 Apr 24. (*equal contribution).

Message

Malaria is a really exciting area of research. If you are interested in malaria, please feel free to contact me.