HOMEAssistant Professor Shinya Miyazaki

Faculty

Assistant Professor Shinya Miyazaki

Speciality / Research theme / Keywords
Parasitology, Molecular Biology, Basic study and drug discovery on malaria parasites, Malaria, Cytoadhesion, Gametocyte, Bone marrow cells, Reporter lines
Supervision
Masters ProgrammeDoctoral Programme

Qualifications

PhD（Pharmacy）, Pharmacist

Personal/work Web page addresses

Researchmap : https://researchmap.jp/shinyamiyazaki

Background

  • Apr 2024-Present
    Assistant professor. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki university, Japan
  • Apr 2020-March-2024
    Assistant professor. Department of Cellular Architecture Studies, Institute of Tropical Medicine (NEKKEN), Nagasaki university, Japan
  • Apr 2017-March-2020
    Postdoctoral fellow. Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
  • Apr 2012-March-2017
    Postdoctoral fellow. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
  • Apr 2007-March-2012
    Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.

 

Research

  • Establishment of a platform to assess the cytoadhesion of Plasmodium falciparum-infected erythrocytes to human cells’
  • Molecular mechanisms of interactions between Plasmodium falciparum-infected erythrocytes and bone marrow cells’
  • Development of Plasmodium falciparum reporter lines for the biology and drug discovery’.
  • Analysis of pathogenicity and transmissibility using Plasmodium falciparum field strains’

The country/countries where you work currently

  • Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Miyazaki Y†, Vos MW, Geurten FJA, Bigeard P, Kroeze K, Yoshioka S, Arisawa M, Inaoka DK, Soulard V, Dechering KJ, Franke-Fayard B, Miyazaki S†. A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays. Communications Biology. 2023 Jul. doi: 10.1038/s42003-023-05078-5 (†Corresponding author)
  2. Tokumasu F†, Hayakwa EH, Fukumoto J, Miyazaki S†. Creative Interior Design by Plasmodium falciparum~ Lipid metabolism and parasite’s secret chamber~Parasitol Int. 2021 Apr 24;83:102369. (†Corresponding author)
  3. Miyazaki S, Chitama BA, Kagaya W, Lucky AB, Zhu X, Yahata K, Morita M, Takashima E, Tsuboi T, Kaneko O. Plasmodium falciparum SURFIN4.1 forms an intermediate complex with PTEX components and Pf113 during export to the red blood cell. Parasitol Int. 2021 Apr 24;83:102358.
  4. Miyazaki S†, Yang ASP, Geurten FJA, Marin-Mogollon C, Miyazaki Y, Imai T, Kolli SK, Ramesar J, Chevalley-Maurel S, van Gemert GJ, van Waardenburg YM, Franke-Fayard B, Hill AVS, Sauerwein RW, Janse CJ†, Khan SM. Generation of novel Plasmodium falciparum NF135 and NF54 lines expressing fluorescent reporter proteins under the control of strong and constitutive promoters. Front Cell Infect Microbiol. 2020 Jun 10;10:270. doi: 10.3389/fcimb.2020.00270. (†corresponding author)
  5. Chitama BA*, Miyazaki S*, Zhu X*, Kagaya W, Yahata K, Kaneko O. Multiple charged amino acids of Plasmodium falciparum SURFIN4.1 N-terminal region are important for efficient export to the red blood cell. Parasitol Int. 2019 Aug;71:186-193. doi:10.1016/j.parint.2019.04.019. Epub 2019 Apr 24. (*equal contribution).

Message

Malaria is a really exciting area of research. If you are interested in malaria, please feel free to contact me.

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